• 9/11/26

A.L.A.N.: The Invisible Poison in Your Home

Artificial light at night is the metabolic poison nobody warned you about. In Part 1 of this two-part series, Dr. Alan Bradford breaks down what happens when you flip on the lights after sunset.

Melatonin and cortisol are supposed to work in opposition: cortisol peaks in the morning, melatonin rises at night. But the moment artificial light hits your eyes, your suprachiasmatic nucleus — the body's master clock — tells your pineal gland to shut melatonin production down.

Research shows light as low as about 8 lux, roughly half a typical night light, starts that suppression. A tablet screen is about 100 times brighter than the full moon. That matters, because melatonin signals your mitochondria, supports SIRT3, and fuels antioxidant defense, while in cancer cells it depletes catalase and pushes those cells toward apoptosis. Dr. Bradford also explains why blue light isn't the villain — you need it in daytime — and why modern LEDs cause problems by over-emitting 430 to 450 nanometers while omitting the 480 nanometer band. You'll get real, actionable steps: no screens one to two hours before bed, dim household lights after sunset, quality blue blockers, automated dimming, and a solid sleep mask. Plus a sneak peek at next week's guest. Cutting through the medical BS, one light switch at a time.

References:

  1. Harvard Health — "Blue light has a dark side" (July 2024).

    https://www.health.harvard.edu/healthy-aging-and-longevity/blue-light-has-a-dark-side

  2. Zhou E. — "Does sleeping with an eye mask improve learning and alertness?" Harvard Health Blog, Feb 21 2024.

    https://www.health.harvard.edu/blog/does-sleeping-with-an-eye-mask-improve-learning-and-alertness-202402213017

  3. Glickman et al. — "Optimizing the Potential Utility of Blue-Blocking Glasses…"

    Transl Vis Sci Technol

    2025;14(7):25.

    https://pmc.ncbi.nlm.nih.gov/articles/PMC12315928/

  4. Gabinet NM — "Effects mediated by melatonin and cortisol of artificial light and noise…"

    Explor Neurosci

    2024;3:382–417.

    https://www.explorationpub.com/Journals/en/Article/100657

  5. Reiter RJ et al. — "Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3."

    Int J Mol Sci

    2018.

    https://pmc.ncbi.nlm.nih.gov/articles/PMC6121285/

  6. "Melatonin as a mitochondria-targeted antioxidant."

    https://pmc.ncbi.nlm.nih.gov/articles/PMC11107735/

  7. IARC/WHO — "IARC Monographs Volume 124: Night Shift Work." 2020.

    https://www.iarc.who.int/news-events/iarc-monographs-volume-124-night-shift-work/

  8. Sleep Education (AASM) — "Screen time and sleep: What new studies reveal."

    https://sleepeducation.org/screen-time-and-sleep-what-new-studies-reveal/

  9. Naaz S, Mishra S, Pal PK, Chattopadhyay A, Das AR, Bandyopadhyay D. Activation of SIRT1/PGC 1α/SIRT3 pathway by melatonin provides protection against mitochondrial dysfunction in isoproterenol induced myocardial injury. Heliyon. 2020 Oct 13;6(10):e05159. doi: 10.1016/j.heliyon.2020.e05159. PMID: 33088945; PMCID: PMC7567935.

  10. Hosseinzadeh A, Seirafianpour F, Sheibani M, Taheri M, Naeini AJ, Reiter RJ, Mehrzadi S. Therapeutic Aspects of Melatonin-sirtuin Crosstalk: An Updated Review of Current Data Based on Cellular Mechanisms. Curr Drug Targets. 2025;26(10):683-708. doi: 10.2174/0113894501360934250512052503. PMID: 40375696.

  11. The University of Iowa Carver College of Medicine. (2017, January 10).

    Why high-dose vitamin C kills cancer cells

    .

    https://medicine.uiowa.edu/news/2017/01/why-high-dose-vitamin-c-kills-cancer-cells

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